note: u probably need to have played the single player game of R1, R2, or Retribution to fully understand the gravity of the following statements.
i had to do some research on the name of a clinical trial for my job. in doing so, i discovered some very shocking news!! this is a real document.
Mantle cell lymphoma (MCL) has a poor prognosis without cure; the median overall survival ranges only from 3 to 4 years irrespective of conventional therapeutic regimens. IDEC-C2B8 (rituximab), a chimeric monoclonal antibody against the B-cell—specific antigen CD20, induces an evaluable clinical response in patients with MCL with mild toxicities. However, the single agent rituximab cannot cure MCL. Due to its low immunogenicity, an antibody against IDEC-C2B8 (human anti-chimeric antibody [HACA]) has rarely been produced in vivo. We report a patient with relapsed MCL who was successfully treated with IDEC-C2B8 for over a year although she developed HACA 6 months after the initial administration of IDEC-C2B8 in the phase II clinical trial conducted by Zenyaku Kogyo Co. Ltd. We followed the pharmacokinetics of IDEC-C2B8, the serum HACA titer, and the number of B lymphocytes in the peripheral blood in relation to clinical response. The HACA became undetectable soon after subsequent administrations of IDEC-C2B8. When the serum level of IDEC-C2B8 was kept elevated, clinical responses were apparently observed and HACA disappeared during this response period. There were no significant clinical toxicities related to the appearance of HACA. The present findings suggested that IDEC-C2B8 is effective and safe even in patients who have developed HACA.
ok. i know this is long. but did u see it??
"Due to its low immunogenicity, an antibody against IDEC-C2B8 (human anti-chimeric antibody [HACA]) has rarely been produced in vivo."
dood... they already know that ppl are turning into Chimera!!! we gotta start building underground shelters and learn how to use alien technology just like in Independence Day, only without all the cheezy 1-liners! i wouldnt mind being turned into a chimera as long as i didnt have to go to work anymore. maybe eating ppls faces wouldnt be so bad?